Mother’s obesity during pregnancy increases the risk of heart disease in children – Study

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We all know that the effect of a mother’s health on the child growing in her womb is very deep. Therefore, it becomes necessary to pay more attention to the health of women at the time of pregnancy. But do you know that the child born to an obese mother at the time of pregnancy may have a risk of heart disease? Scientists from the University of Colorado of America have claimed this in their new study. According to the researchers, this is the first study in itself to show that maternal obesity causes molecular changes in the fetal heart and that it alters gene expression related to nutrient metabolism, which is important in later life. It greatly increases the risk of heart-related problems in the child.

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The findings of this study are published in the Journal of Physiology. published Has happened. For this study, researchers from the University of Colorado, USA, used a mouse model. Because in them the human maternal physiology and the nutritional supply through the umbilical cord are found to be the same.

How did the study happen?
During the research, rats were given high-fat food items as well as sugary drinks, which is equivalent to the human consumption of burgers, chips and fizzy (added gas) drinks. This diet is given to the rats till their weight does not exceed 25% of their original normal weight. Whereas 50 rats were given food as a control. After this, along with studying the embryos of mice, imaging techniques were also examined at 3, 6, 9 and 14 months after the birth of the child. These included scans such as echocardiogram and positron emission tomography (PET). Based on this, the genes, proteins and mitochondria of the children were analyzed.

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What happened in the study
Researchers found that changes in cardiac metabolism in children largely depended on gender. The female fetus had 841 gene expression changes, while the male fetus had 764 gene expression changes. Only 10% of the modified genes were common in both sexes. Despite this, interestingly, disturbances in cardiac function were found in both male and female children born to obese mothers. However, there is a difference in the development of heart defects in both the sexes. Heart disturbances start earlier in male children, whereas in females the condition worsens with increasing age.

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Researchers say that differences in cardiovascular health and its functioning may be due to the hormone estrogen. Cardiovascular health is protected by high levels of estrogen in young age, while protection is lost when estrogen levels drop as we age. This difference on gender basis could not be understood on molecular basis.

what the experts say
The study’s main author, Dr. Owen Vaughan, of the University of Colorado, said, “Our study indicates that there is a process or mechanism between maternal obesity and cardiometabolic disease in the next generation.” . This study is important in this sense, because obesity is increasing day by day in the human population and about one-third of women of childbearing age suffer from it. In such a situation, developing an understanding of the mechanism or mechanism of risk to children due to obesity can lead to finding a cure or prevention of cardiometabolic diseases.

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He further said, ‘In the direction of prevention, nutrition can be advised to mothers or children based on their body mass index or a drug can be developed, which can correct the metabolism of the heart in the embryonic stage itself. work to do’

Tags: Health, Health News, Lifestyle



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