What are the changes in the brain during the treatment of depression, the study revealed


Depression means that the effect of treatment of depression is understood so slowly that it becomes difficult to ascertain whether the treatment that is going on is effective or not. In such a situation, if there is a need for change in the middle of treatment, then it is difficult to decide. But now researchers from the University of British Columbia (UBC) have developed their new Study It has been shown in the study that what happens in the brain during repetitive transcranial magnetic stimulation (rTMS) treatment. Let us tell you that the process of rTMS is adopted in the case when the drug is not effective in the treatment of depression. In such a situation, it becomes even more important to know the effect of this method. It is estimated that 40% of people with depression are not affected by antidepressant medication. In this situation, a device containing an electromagnetic coil is placed on the patient’s scalp during the rTMS session. The device delivers a magnetic pulse without causing pain, which stimulates nerve cells in areas of the brain involved in mood control. This is called the Dorsolateral Prefrontal Cortex.


Despite this process being proven effective, it was not known how rTMS affects the brain and what is its mechanism? The findings of this study were published in the American Journal of Psychiatry. published Has happened.

what the experts say
Assistant Professor in UBC’s Department of Psychiatry Dr. Fidel Villa-Rodriguez According to, ‘When we started this study, we had a simple question, what happens in the brain during rTMS treatment? To answer this question, our team gave patients rTMS while they were in a magnetic resonance imaging (MRI) scanner. Since MRI can measure brain activity, the changes during rTMS were detected in real time.

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The research team found that stimulating the dorsolateral prefrontal cortex activated several areas of the brain. These areas are related to tasks ranging from managing emotional reactions to motley control. The research team treated study participants with rTMS for four weeks and investigated whether the areas of the brain that were activated were associated with a reduction in depression symptoms in the patients.

What happened in the study
Dr Villa-Rodriguez said that the areas of the brain that were activated during rTMS and functional MRI had a significant association with positive results. He said that through this new map, it became easy to find out how rTMS stimulates different parts of the brain. We hope this can be used to determine how a patient responds to rTMS.

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He added that by demonstrating this principle and identifying the area of ??the brain that is activated through rTMS, we can now try to understand whether this pattern can be used as a biomarker. Researchers are now exploring how rTMS could be used in other neuropsychiatric diseases.

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