Why does coronavirus become serious in lung patients, study revealed


Coronavirus and Lungs Problem: Patients with lung diseases are more prone to severe corona infection, but researchers have now discovered that covid infection is common in people with chronic obstructive pulmonary disease (COPD). Why is the comparison serious? With this, new treatment will also be found to save people with lung disease from serious condition. Researchers from Australia’s Centenary Institute and University of Technology Sydney Study It was found that in the condition of SOPD, the windpipe gets blocked, which makes breathing difficult. Around 400 million people are suffering from this disease worldwide.


The findings of this study are published in the American Journal of Respiratory and Critical Care Medicine. published Has been done. For the study, researchers removed cells from the windpipes of COPD patients and healthy people and infected them with SARS-CoV-2 (the cause of corona). They found that windpipe cells with SOPD were 24 times more likely to have infections than healthy cells.


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what the experts say
The study’s main author and researcher Matt Johansen of the Centenary UTS Center for Inflammation said that its genetic information was collected through RNA sequencing of the infected cell. Seven days later, it was found that the SARS-CoV-2 infection viral load was 24 times higher in cells from patients with COPD than cells taken from healthy individuals.


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He further added, “COPD is an inflammatory disease in which patients have increased inflammation at baseline compared to healthy people. So it is more likely that SARS-CoV-2 exacerbates this current high inflammation, making the results worse.”

What happened in the study
The research team also found during the study that the levels of transmembrane protease serine 2 (TMPRSS2) and cathepsin B (CTSB) were increased in infected cells with COPD. SARS-CoV-2 (SARS CoV 2) uses both of these enzymes to enter the host cell. Because COPD patients have elevated levels of these two enzymes, conditions are more favorable for infection in people with COPD than in healthy humans.

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